Table 4.

Relationship of serum OC and CTX with BMD at the total hip and femoral neck

	Total Hip			Femoral Neck
	Beta per SD increment	95% C.I.	p	Beta per SD increment	95% C.I.	p
OC
Model 1	−0.025	−0.038, −0.012	<0.001	−0.022	−0.034, −0.011	<0.001
Model 2	−0.018	−0.030, −0.006	0.003	−0.016	−0.026, −0.005	0.004
Model 3	−0.020	−0.033, −0.008	0.002	−0.016	−0.027, −0.005	0.006
Model 4	−0.021	−0.033, −0.008	0.002	−0.017	−0.028, −0.005	0.004
CTX
Model 1	−0.025	−0.037, −0.014	<0.001	−0.021	−0.032, −0.011	<0.001
Model 2	−0.018	−0.029, −0.007	0.001	−0.015	−0.025, −0.005	0.003
Model 3	−0.019	−0.031, −0.007	0.001	−0.014	−0.024, −0.004	0.009
Model 4	−0.019	−0.031, −0.007	0.002	−0.015	−0.025, −0.004	0.006

C.I., confidence interval.

Model 1: adjusted for age, race, field center and season.

Model 2 additionally adjusted for BMI, education, smoking status, alcohol consumption, physical activity, estrogen replacement therapy.

Model 3 additionally adjusted for systolic blood pressure, anti-hypertensive therapy, diabetes, calcium supplementation, LDLc, HDLc, triglycerides, prevalent CHD, prevalent CHF, prevalent claudication, prevalent AF, prevalent stroke/TIA, eGFR, C-reactive protein.

Model 4 additionally adjusted for ADL impairment, cognitive impairment and fall history.