. Author manuscript; available in PMC: 2020 Oct 1.

Published in final edited form as: Eur Radiol. 2019 Apr 1;29(10):5367–5377. doi: 10.1007/s00330-019-06168-x

Table 4:

MPM assigned categories breakdown of nodule risk prediction. Refer to Supplemental Table A.2 for complete size-based breakdown.

MPM	Nodule Size	Malignancy probability and associated clinical guidelines for treatment/ nodule evaluation
MC		< 3% Watchful waiting	3–68% Needle biopsy	> 68% Surgery
	All	0M: 6B	61M: 225B	19M: 6B
	All	0% malignant wait	98% benign immediate work-up
	≥ 8mm to < 15mm	0M: 0B	26M: 91B	1M: 1B
	≥ 8mm to < 15mm	0% malignant wait	100% benign immediate work-up
	≥ 15mm	0M: 0B	24M: 24B	18M: 6B
	≥ 15mm	0% malignant wait	100% benign immediate work-up
VA		< 20% Watchful waiting	20–69% Needle biopsy	> 69%Surgery
	All	7M: 58B	51M: 163B	22M: 16B
	All	9% malignant wait	76% benign immediate work-up
	≥ 8mm to < 15mm	1M: 13B	25M: 75B	1M: 4B
	≥ 8mm to < 15mm	4% malignant wait	86% benign immediate work-up
	≥ 15mm	3M: 0B	18M: 18B	21M: 12B
	≥ 15mm	7% malignant waits	100% benign immediate work-up
BU		< 10% Low risk	≥ 10% Higher Risk
	All	20M: 177B	60M: 60B
	All	25% malignant wait	25% benign extra procedures
	≥ 8mm to < 15mm	9M: 61B	18M: 31B
	≥ 8mm to < 15mm	33% malignant wait	34% benign immediate work-up
	≥ 15mm	0M: 1B	42M: 29B
	≥ 15mm	0% malignant wait	97% benign immediate work-up
PU		< 46.3% Nodule considered benign	≥ 46.3% Nodule considered malignant
	All	8M: 87B	72M: 150B
	All	10% malignant wait	63% benign immediate work-up
	≥ 8mm to < 15mm	3M: 33B	24M: 59B
	≥ 8mm to < 15mm	7% malignant wait	64% benign immediate work-up
	> 15mm	3M: 4B	39M: 26B
	> 15mm	7% malignant wait	87% benign immediate work-up

Definition of abbreviations: MPM – mathematical prediction model; MC – Mayo Clinic; VA – Veteran’s Affairs; BU – Brock University; PU – Peking University; M – malignant; B - benign