Table 4.
Prognostic test properties for prominent diffusion MRI sensorimotor biomarkers.
| Biomarker | Threshold | AUC (95% CI) |
Sensitivity (95% CI) |
Specificity (95% CI) |
Positive LR (95% CI) |
Negative LR (95% CI) |
P |
|---|---|---|---|---|---|---|---|
| STRs FA | 0.1383 | 0.800 (0.560, 1.000) |
60.0% (14.7%, 95.7%) |
100.0% (90.3%, 100.0%) |
∞ | 0.40 (0.14, 1.17) |
<0.001 |
| CST RD | 0.00135 | 0.686 (0.444, 0.927) |
40.0% (5.3%, 85.3%) |
97.1% (85.1%, 99.9%) |
14.0 (1.54, 127.6) |
0.62 (0.30, 1.27) |
0.036 |
| STRm AD | 0.00172 | 0.686 (0.444, 0.927) |
40.0% (5.3%, 85.3%) |
97.1% (85.1%, 99.9%) |
14.0 (1.54, 127.6) |
0.62 (0.30, 1.27) |
0.036 |
| Combined* | see above |
0.886 (0.688, 1.000) |
80.0% (28.4%, 99.5%) |
97.1% (85.1%, 99.9%) |
28.0 (3.9, 203.0) |
0.21 (0.04, 1.19) |
<0.001 |
*
Combination of STRs FA and CST RD biomarkers or STRs FA and STRm AD biomarkers
STRs – superior thalamic radiations, sensory; FA – fractional anisotropy; CST – corticospinal tract; RD – radial diffusivity; STRm – superior thalamic radiations, motor; AD – axial diffusivity; AUC – area under receiver operating characteristic curve; LR – likelihood ratio