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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Hepatology. 2019 Jun 24;70(3):995–1010. doi: 10.1002/hep.30691

Figure 1. Genetic activation of PXR and Pxr ablation sensitize mice to and protect mice from HS-induced liver injury, respectively.

Figure 1.

(A) WT, VP-PXR transgenic, and Pxr−/− mice subject to sham surgery or HS/R were analyzed for liver injury by H&E staining. The “N”s within the dotted circle indicate the necrotic areas. Bar is 100 μm. (B-E) Mice are the same as in (A). Shown are quantification of necrotic areas (B), Suzuki scores of the liver damage (C), and serum levels of ALT (D), and hepatic expression of Cyp3a11 and Cyp2b10 (E). (F) Mice in (A) were analyzed for lung injury by H&E staining. n=4~5 for each group. *, p < 0.05; **, p < 0.01, compared to the WT (B and C), or the comparisons are labeled (D and E).