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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Hepatology. 2019 Jun 24;70(3):995–1010. doi: 10.1002/hep.30691

Figure 7. Post-hemorrhagic shock activation of PXR sensitizes mice to HS-induced hepatic injury.

Figure 7.

(A) Schematic representation of the model of post-HS treatment of PCN or DEX. WT mice were subject to a 2-h HS and intraperitoneally injected with PCN (40 mg/kg) or DEX (20 mg/kg) before the resuscitation, and the mice were sacrificed 22 h after. (B) The hepatic mRNA expression of Cyp3a11 was measured by qRT-PCR. (C) Liver histology was analyzed by H&E staining. Shown on the right are quantification of necrotic areas and Suzuki scores. (D) Serum levels of ALT. (E) Immunofluorescent staining for 8-OHdG. Bar is 100 μm. n=4~5 for each group. *, p < 0.05; **, p < 0.01, the comparisons are labeled (B and D), or compared to the VEH group (C).