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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Eur J Pharm Biopharm. 2019 Jun 18;142:153–164. doi: 10.1016/j.ejpb.2019.06.005

Figure 2.

Figure 2.

The concentration-time profiles of (A) total drug (free + encapsulated), (B) free payload, (C) encapsulated nanoparticles, (D) DNA-binding drug and (E) intracellular free drug in the three tumor anatomical layers in a 10 cm3 tumor spheroid in a 70-kg man after dosed at 50 mg/m2 of Doxil.