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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Eur J Pharm Biopharm. 2019 Jun 18;142:153–164. doi: 10.1016/j.ejpb.2019.06.005

Figure 4.

Figure 4.

The combined effects of influencing factors (the effect by simultaneously changing two factors) on free payload tumor delivery efficiency (ID%) in well-diffused tumor. The colors represent the free payload ID%. The red circles represent Doxil in typical solid breast tumors. BP: tumor blood perfusion; CL: nanoparticle systemic clearance; DC: the nanoparticle diffusion coefficient in the tumor extracellular matrix; VP: nanoparticle vascular permeability; RC: the nanoparticle release constant in the tumor extracellular matrix.