Table 5.
Metrics to evaluate the Doxil disposition in tumor
| Tumor type | r1:r2:r3 | Metrics | Proximal layer | Intermediate layer | Distal layer | Total | H index |
|---|---|---|---|---|---|---|---|
| Well diffused tumor | 60:30:10 | Total doxorubicin (ID%) | 0.0394 | 0.0174 | 3.11E-4 | 0.0574 | 0.154 |
| Free doxorubicin (ID%) | 0.0157 | 8.14E-3 | 2.50E-4 | 0.0242 | 0.194 | ||
| Encapsulated doxorubicin (ID%) | 0.0237 | 9.28E-3 | 6.09E-5 | 0.0332 | 0.126 | ||
| EPRC | 0.248 | 0.423 | 0.411 | 0.309 | |||
| TSE | 0.0740 | 0.0708 | 0.0216 | 0.0555 | |||
| Moderately diffused tumor | 30:40:30 | Total doxorubicin (ID%) | 0.0402 | 3.32E-3 | 1.58E-6 | 0.0437 | 8.21E-3 |
| Free doxorubicin (ID%) | 9.21E-3 | 1.20E-3 | 1.31E-6 | 0.0105 | 0.0130 | ||
| Encapsulated doxorubicin (ID%) | 0.0310 | 2.12E-3 | 2.70E-7 | 0.0332 | 6.73E-3 | ||
| EPRC | 0.303 | 0.554 | 0.511 | 0.332 | |||
| TSE | 0.0973 | 0.0275 | 7.75E-4 | 0.0419 | |||
| Poorly diffused tumor | 10:30:60 | Total doxorubicin (ID%) | 0.0344 | 9.64E-4 | 2.00E-7 | 0.0355 | 1.20E-3 |
| Free doxorubicin (ID%) | 2.06E-3 | 2.24E-4 | 2.00E-7 | 2.30E-3 | 4.65E-3 | ||
| Encapsulated doxorubicin (ID%) | 0.0323 | 7.40E-4 | 0 | 0.0332 | 9.78E-4 | ||
| EPRC | 0.331 | 0.809 | 1 | 0.378 | |||
| TSE | 0.0986 | 0.0189 | 5.66E-5 | 0.0392 |
r1: radius of proximal layer, r2: radius of intermediate layer, r3: radius of distal layer.