Figure 1.

Location, type and distribution of ETV6 and RUNX1 germline alterations detected in childhood acute lymphoblastic leukemia (ALL) patients. (A) ETV6 and (B) RUNX1 germline variants of the current study, observed in childhood ALL patients developing secondary malignant neoplasms (SMN) are indicated by rhombs and black lines. ALL-related germline alterations reported in the literature^7,9,12,13,16 are represented by circles and gray lines. Germline variants published for childhood ALL patients developing SMN¹² are indicated by rhombs and gray lines. Only one individual from each kindred, reported in the literature, was included for plotting.^9,12,16