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Central haemodynamic responses. a) Cardiac output; b) systemic vascular conductance; c) systemic CaO2; and d) systemic oxygen delivery recorded at rest, at the time of exhaustion in room air (isotime), and at the limit of exercise tolerance (tlim) while breathing normoxic heliox, pure (100%) oxygen or room air. Isotime data are those obtained on normoxic heliox or 100% oxygen at the same time as at the limit of exercise tolerance on room air.
