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A schematic representation conceptualising the acute physiological responses a patient with COPD exhibits during exercise breathing heliox or oxygen compared with exercise in room air. tE: expiratory time; DH: dynamic hyperinflation; CO: cardiac output; O2DEL: oxygen delivery; SVC: systemic vascular conductance; EMG: electromyography. #: profoundly in hypoxaemic patients. Figure partially created using BioRender.
