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. Author manuscript; available in PMC: 2020 Sep 15.
Published in final edited form as: Acta Biomater. 2019 Jul 3;96:385–399. doi: 10.1016/j.actbio.2019.06.050

Table 3:

Linear models were used to investigate the correlation of IOP decrease (mmHg) and percent IOP decrease (%) with average Ezz, Emax, and Γmax strains within the full, central, and peripheral ALC. Bolded p-values represent significant correlations. There was a significant positive correlation between IOP decrease and average ALD change in the LC (p = 0.0135), and a significant positive correlation between percent IOP decrease and average Emax within the peripheral ALC (p = 0.0017), average Γmax within the peripheral ALC (p = 0.0126), and average Ezz (p = 0.0001) in the central ALC. IOP decrease correlated similarly with strains, but with less significance.

Linear correlation: LC deformation and IOP LC Region Mean change per 10 mmHg IOP decrease (95% CI) R2 p-value (linear model) Mean change per 10% IOP decrease (95% CI) R2 p-value (linear model)
ALD Change (μm) Full 2.556 (0.689 4.424) 0.555 0.0135 0.604 (0.012 1.197) 0.409 0.0466
Central 2.493 (0.594 4.392) 0.534 0.0164 0.560 (−0.055 1.175) 0.355 0.0691
Peripheral 2.547 (0.568 4.525) 0.524 0.0179 0.642 (0.050 1.233) 0.439 0.0368
Ezz Strain (10−2) Full 0.284 (0.051 0.516) 0.497 0.0228 0.093 (0.044 0.142) 0.704 0.0024
Central 0.341 (0.144 0.538) 0.666 0.0040 0.106 (0.070 0.142) 0.850 0.0001
Peripheral 0.153 (−0.155 0.460) 0.141 0.2852 0.066 (−0.008 0.140) 0.345 0.0744
Emax Strain (10−2) Full 0.371 (−0.039 0.780) 0.353 0.0702 0.121 (0.022 0.220) 0.497 0.0228
Central 0.317 (−0.157 0.791) 0.229 0.1615 0.111 (−0.006 0.229) 0.374 0.0604
Peripheral 0.484 (0.161 0.806) 0.600 0.0085 0.147 (0.073 0.220) 0.726 0.0017
Γmax Strain (10−2) Full 0.287 (−0.045 0.619) 0.331 0.0817 0.093 (0.011 0.175) 0.458 0.0316
Central 0.276 (−0.156 0.708) 0.214 0.1786 0.101 (−0.004 0.207) 0.381 0.0574
Peripheral 0.347 (0.104 0.591) 0.576 0.0110 0.094 (0.026 0.163) 0.561 0.0126