Skip to main content
. Author manuscript; available in PMC: 2020 Sep 15.
Published in final edited form as: Acta Biomater. 2019 Jul 19;96:686–693. doi: 10.1016/j.actbio.2019.07.028

Fig. 5:

Fig. 5:

In vivo response of the surface treated Ti substrates in a rat distal femur model 5 weeks after implantation. (a) CT scan images exhibiting proper lodging of the implant into the femur bone of the animals (b) SEM micrographs of CpTi (inset – higher magnification image of an interfacial gap), TNT and TNT-P showing improved osseointegration through higher osseous tissue-implant interlocking for TNT-P and (c) optical micrographs for CpTi, TNT and TNT-P showing the presence of both osteoids like bone as well as mineralized bone formations d) Histomorphometric analysis of OS/BS and MS/BS around implants 5 weeks post-surgery. The TNT-P samples show significantly higher mineralized bone in the vicinity of the implant as compared to the TNT and CpTi at an early 5-week time point. Osteoid surface was comparable between TNT and TNT-P and was higher than CpTi. ANOVA results for sample comparisons, n=6 and α=0.05. P-values between CpTi and TNT-P and between CpTi and TNT-P are less than 0.001 (significant*) and less than 0.0001 (extremely significant**), respectively.