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. Author manuscript; available in PMC: 2020 Sep 1.
Published before final editing as: Neurosci Res. 2019 Mar 1:S0168-0102(19)30021-5. doi: 10.1016/j.neures.2019.02.007

Figure 4.

Figure 4

Phosphorylation levels of DARPP-32 and GluA1 in the NAc. Brain slices of the NAc were assessed for phosphorylation levels of DARPP-32 and GluA1 using 10 μM rolipram. Effects of rolipram were measured by phosphorylation levels at Thr34 of DARPP-32 (a) and Ser845 of GluA1 (b), which are PKA sites. (a) Phosphorylation levels at Thr34 of DARPP-32 in the NAc were significantly elevated by treatment with rolipram. The effect of rolipram was significantly greater in the GXE group compared with other groups. * p < 0.05. CTL, n = 8; E, n = 7; G, n = 7; GXE, n = 7. (b) Phosphorylation levels at Ser845 of GluA1 in the NAc were significantly elevated by treatment with rolipram. The effect of rolipram was significantly greater in GXE mice when compared with G, E, and CTL mice. ** p < 0.01. CTL, n = 9; E, n = 8; G, n = 8; GXE, n = 7.