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. Author manuscript; available in PMC: 2020 Sep 1.
Published before final editing as: Neurosci Res. 2019 Mar 1:S0168-0102(19)30021-5. doi: 10.1016/j.neures.2019.02.007

Figure 5.

Figure 5

Effects of rolipram or saline on cocaine-related behaviors (a, b) Rolipram (0.1 mg/kg, i.p.) or saline was administered 20 min before cocaine (10 mg/kg) injections. (a) Repeated cocaine produced a significantly greater sensitization of locomotor activity in GXE mice than CTL, E, and G mice (Saline). Co-administration of rolipram blocked the augmentation of cocaine-induced locomotor sensitization in GXE mice (Rolipram). ** p < 0.01. n = 7 each. (b) In a CPP test, preference for the cocaine-paired side was significantly elevated in GXE mice when compared with CTL, E, and G mice (Saline). Co-administration of rolipram completely blocked cocaine-induced conditioned place preference in GXE, but not CTL, E, or G mice (Rolipram). * p < 0.05, ** p < 0.01. n = 5 each.