Table 4:

Disregulation of energy and lipid metabolism genes in Cyp3a-null mice after eight weeks of HFD treatment.

Genes	WT	Cyp3a-null	WT	Cyp3a-null
Acox	1.00±0.111	0.885±0.145	1.00±0.140	0.623±0.111
ApoE	1.00±0.160	1.411±0.273	1.00±0.156	0.437±0.107*
Car	1.00±0.116	1.769±0.430	1.00±0.198	0.564±0.052
Cpt1a	1.00±0.093	1.152±0.196	1.00±0.129	0.510±0.083**
Fasn	1.00±0.152	0.871±0.164	1.00±0.184	0.450±0.067*
Fatp-1	1.00±0.312	2.259±0.637	1.00±0.217	2.088±0.416*
Foxa2	1.00±0.182	1.354±0.247	1.00±0.202	1.052±0.137
IL-6	1.00±0.150	2.018±0.454*	1.00±0.222	0.640±0.141
Pepck1	1.00±0.193	1.199±0.327	1.00±0.298	0.397±0.105
Pparα	1.00±0.122	1.201±0.164	1.00±0.211	0.970±0.168
Pparγ	1.00±0.053	1.296±0.207	1.00±0.327	0.878±0.153
Pxr	1.00±0.158	1.919±0.386*	1.00±0.234	0.407±0.075*
Srebp1	1.00±0.127	0.967±0.213	1.00±0.145	0.567±0.058*
Srebp1a	1.00±0.254	1.118±0.346	1.00±0.188	0.466±0.120*
Srebp1c	1.00±0.127	1.355±0.266	1.00±0.160	0.536±0.131
Cyp2b9	1.00±0.137	1.495±0.154*	1.00 ±0.340	4.250±3.585
Cyp2b10	1.00±0.210	1.283±0.176	1.00 ±0.202	1.819±0.331

Data represented as relative mean +/− SEM (n = 7 or 8). Statistical significance determined by Student’s t-test.

^*Indicates a p-value ≤ 0.05 and

^**Indicates a p-value ≤ 0.01.