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. 2019 Aug 27;12:6927–6936. doi: 10.2147/OTT.S218240

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© 2019 Liu et al.

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Estrogen enhanced NLPR3 inflammasome activation and endometrial cancer cell proliferation in vitro. (A–C) Ishikawa cells were treated with estrogen, ICI182870 or PHTPP for 24 hrs and relative levels of NLPR3, ERα, ERβ, IL-1β were determined by Western blot. (D) The expression of NLPR3 and ERβ in human endometrial cancer tissues was examined by immunohistochemistry (magnification ×400). (E) Estrogen promoted the proliferation of Ishikawa cells and NLRP3 silencing dramatically reversed the effects. (F) Blockage of ERβ inhibited the proliferation of Ishikawa cells and NLRP3 overexpression dramatically reversed the effects. Data are representative images or expressed as mean ± SEM of each group. *P<0.05, **P<0.01, ***P<0.001.