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. 2019 Aug 27;14:6917–6932. doi: 10.2147/IJN.S213084

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© 2019 Wei et al.

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Fluorescence imaging intracellular Hg²⁺ of L929 cells with free C-DMSA or C-DMSA loaded mixed micelles (A); cell viability of L929 cells treated with Hg²⁺ and different treatments with untreated cells and poisoning group served as controls (B).

Notes: Left column, cells without Hg²⁺ pretreatment; right column, cells with Hg²⁺ pretreatment; top row, cells treated with PBS (blank); middle row, cell treated with C-DMSA (20 μg/mL); bottom row, cells treated with C-DMSA@VES-g-CSO/VES-g-CS MM. **p<0.01, compared to control group; ^##p<0.01, compared to poisoning group. Data were presented as mean±SD (n=6).

Abbreviations: DMSA, meso-2,3-dimercaptosuccinic acid; C-DMSA; 3-formyl-7-diethylamino coumarin masked meso-dimercaptosuccinic acid; C-DMSA@VES-g-CSO/VES-g-CS MM, C-DMSA loaded micelles, vitamin E succinate-grafted-chitosan oligosaccharide/vitamin E succinate-grafted-chitosan mixed micelles.