Table S2.

Pharmacokinetic parameters of C-DMSA after a single dosage intravenous administration to rats

Pharmacokinetic parameters	C-DMSA	C-DMSA@VES-g-CSO/VES-g-CS MM
t1/2α (h)	0.12±0.01	0.74±0.12**
t1/2β (h)	1.91±0.20	15.23±1.20**
Vd (L/kg)	0.21±0.06	0.17±0.04
AUC0-24h (μg·h/L)	9.96±0.26	45.59±1.37***
CL (L/h/kg)	0.49±0.07	0.10±0.02**

Notes: All the rats were received the single dosage at an equivalent dose of C-DMSA (10 mg/kg). **p<0.01, ***p<0.001, compared to C-DMSA group. Data were presented as mean±SD (n=3).

Abbreviations: t_1/2α, a rapid distribution half-life; t_1/2β, elimination half-life; AUC, the area under the concentration-time curve; V_d, the apparent volume of the central chamber; CL, clearance; C-DMSA, 3-formyl-7-diethylamino coumarin masked meso-dimercaptosuccinic acid; C-DMSA@VES-g-CSO/VES-g-CS MM, C-DMSA loaded vitamin E succinate-grafted-chitosan oligosaccharide/vitamin E succinate-grafted-chitosan mixed micelles.