Figure 10.

Summary schemes of the effect of deficient skin lipid lamellae on evaporative cooling and energy balance. On the left are summary images of the skins evaluated by this study, illustrating the heat losses from each type of skin by evaporative cooling. On the right are schemes that show the calculated energy flow through the system, taken from Table 2 and Table S1. For each strain, the changes in energy expenditure (EE) are calculated and expressed as a % difference compared to control. The power lost to evaporative cooling is expressed as a proportion (%) of change of EE, where increases are shown in red, and decreases are shown in blue. Thus for mice with normal hair (such as Sdc1 KO), increased evaporative cooling accounts for the majority of increased energy expenditure (86%); for strains that lose their hair, evaporative cooling accounts for approximately half of the increased metabolic rate, the rest probably reflects radiative losses.