Fig. 1. Concentration-dependent inhibition of 5-hydroxytryptamine type 3 (5-HT₃) receptor currents by mosapride.

(A) Representative current traces induced by 3 µM 5-HT co-applied with 0.3, 1, 3, 10, 30 µM mosapride. The open horizontal bar indicates the drug application period. Mosapride alone did not induce any current even at high concentration (indicated by arrowhead). (B) Averaged concentration-dependent inhibition of mosapride on the 5-HT₃ receptor current peak amplitude. The data were normalized values (○) to the peak amplitude induced by 3 µM 5-HT alone and a line was obtained from fitting these data to equation (2) in the Methods. (C) Averaged concentration-dependent block of the 5-HT₃ receptor current rise slope by mosapride. Mosapride concentration-dependently decreased the rise slopes of currents at low concentrations (0.3, 1, 3 µM). The data are expressed as means ± standard error of the mean.