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. 2019 Aug 28;12:6981–6990. doi: 10.2147/OTT.S214588

Figure 3.

Figure 3

MiR-149-3p was a target of LINC00665. (A) Architecture of LINC00665 genomic region according to the University of California, Santa Cruz database. (B, C) Target sequences of miR-149-3p in LINC00665. (D) LINC00665 inhibition increased miR-149-3p expression in gastric cancer (GC) cells. (E, F) The interaction between LINC00665 and miR-149-3p was confirmed by luciferase reporter assay (E) and pull-down assay (F). (G) Expression of miR-149-3p in GC tissues was measured by qRT-PCR. (H, I) Low miR-149-3p expression was associated with poor relapse free survival (H) and overall survival (I) of GC patients. (J) miR-149-3p mimics reduced GC cells colony formation ability. *P<0.05.