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. 2019 Aug 28;12:6981–6990. doi: 10.2147/OTT.S214588

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© 2019 Qi et al.

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LINC00665 regulated RNF2 by absorbing miR-149-3p. (A) miR-149-3p and its putative binding sequence sites in the RNF2 3′UTR. (B) miR-149-3p mimics reduced the luciferase activity of RNF2-Wt group, but not RNF2-Mut group. (C) miR-149-3p mimics reduced RNF2 protein expression in gastric cancer (GC) cells. (D) LINC00665 expression was positively associated with RNF2 expression in GC tissues. (E) RNF2 protein expression was suppressed in sh-LINC00665 group, while miR-149-3p inhibitors rescued the effects. (F) IHC determined RNF2 expression in GC tissues and normal tissues. (G) RNF2 expression in GC tissues was determined by GEPIA database. (H, I) High RNF2 expression was associated with poor relapse free survival (H) and overall survival (I) of GC patients. *P<0.05.