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经Ommaya囊脑室内注射化疗药物治疗软脑膜转移的研究总结

Summary of studies and cases evaluating intrathecal chemotherapy through Ommaya reservoir for LM

Reference	Primary tumor	n	Drug	Complication (%)	Medianbr survival (d)
CNS: central nervous system; MTX: Methotrexate; cytarabine: Ara-C; SCLC: small cell lung cancer; Median survival (days): Median survival from Ommaya placement to death; Complications: complications related to placement; NSCLC: non-small cell lung cancer. NA：Not available.
Bzdil et al[22]	Solid tumors	107	NA	9.3	270
Obbens et al[23]	Solid tumors	387	NA	6.9	NA
Yoshida et all[24]	Lymphoma >> lung > breast	58	MTX	NA	720
Lavrador et al[25]	Breast >> lung > others solid tumor	23	MTX	NA	185
Roguski et al[6]	Solid tumor >> Hematologic > primary CNS	80	NA	15.8	72.5
Pardo et al[26]	Hematologic	107	MTX liposomal Ara-C	14	NA
Chamberlain et al[27]	Breast > lymphoma > melanoma > primary CNS	120	Liposomal cytarabine	11.4	NA
Zairi et al[28]	Breast > lung > melanoma	112	Liposomal cytarabine	9.8	NA
Sandberg et al[29]	Solid tumors	107	NA	9.3	270
Liaw et al[30]	Breast cancer	42	MTX	NA	161
Hitchins et al[14]	SCLC > Breast	44	MTX Ara-C	NA	125
Lishner et al[31]	Hematologic	106	MTX	8.4	NA
Gwak et al[32]	NSCLC	59	MTX	NA	122