TABLE 1:

C. trachomatis known Inc proteins^a.

Inc protein (annotation/name)			Host cell protein targetsb	Proposed functions	References
Strain D/UW3	Strain L2/434	General
CT005	CTL0260	IncV	VAPA/B	Formation of ER-inclusion MCS; non-vesicle lipid uptake by C. trachomatis.	[52, 59, 125, 189]
CT006	CTL0261	-	Unknown	Unknown.	[59]
CT101	CTL0356	MrcA	ITPR3	Promotion of chlamydial extrusion; localize at inclusion microdomains.	[52, 128, 130]
CT115	CTL0370	IncD	CERT	Formation of ER-inclusion MCS; non-vesicle lipid uptake by C. trachomatis.	[50, 51, 120]
CT116	CTL0371	IncE	SNX5/6	Modulation of retromer-dependent trafficking.	[50, 51, 59, 86–88]
CT117	CTL0372	IncF	Unknown	Heterophilic Inc-Inc interactions.	[50, 51, 59, 75]
CT118	CTL0373	IncG	14-3-3β	Unknown; associates with LDs.	[50, 51, 145, 221]
CT119	CTL0374	IncA	VAMP3/7/8	Homotypic inclusion fusion; regulation of host cell vesicular trafficking; associates with LDs.	[8, 48, 50, 51, 69, 74, 77, 78, 189, 220]
CT134	CTL0389	-	Unknown	Unknown.	[59]
CT135	CTL0390	-	Unknown	Important for chlamydial virulence in a mouse infection model.	[59, 149, 150]
CT147	CTL0402	-	Unknown	Unknown.	[50, 59, 65]
CT179	CTL0431	-	Unknown	Unknown.	[59]
CT192	CTL0444	-	Unknown	Unknown.	[59]
CT222	CTL0475	-	Unknown	Heterophilic Inc-Inc interactions; localizes at inclusion microdomains.	[52, 59, 75, 128]
CT223	CTL0476	IPAM	CEP170	Modulation of the microtubule network; inhibition of host cell cytokinesis; localizes at inclusion microdomains.	[49, 50, 52, 59, 109, 133]
CT224	CTL0477	-	Unknown	Inhibition of host cell cytokinesis; localizes at inclusion microdomains.	[52, 59, 133]
CT225	CTL0477A	-	Unknown	Inhibition of host cell cytokinesis.	[50, 52, 133]
CT226	CTL0478	-	Unknown	Unknown.	[50, 52, 56, 59]
CT227	CTL0479	-	Unknown	Unknown.	[52, 59]
CT228	CTL0480	-	MYP1	Inhibition of chlamydial extrusion; localizes at inclusion microdomains.	[50, 52, 138, 140]
CT229	CTL0481	CpoS	RABs	Control of inclusion membrane stability and/or host cell death, and of host cell vesicular trafficking.	[49, 50, 52, 59, 96–98, 100]
CT232	CTL0484	IncB	Unknown	Localizes at inclusion microdomains.	[50, 59, 128]
CT233	CTL0485	IncC	Unknown	Control of inclusion membrane stability; localizes at inclusion microdomains.	[49, 50, 59, 100]
CT249	CTL500A	-	Unknown	Unknown.	[50, 52, 57]
CT288	CTL0540	-	CCDC146	Localizes at inclusion microdomains.	[49, 50, 59, 135]
CT345	CTL0599	-	Unknown	Unknown.	[59]
CT358	CTL0612	-	Unknown	Unknown.	[50]
CT383	CTL0639	-	Unknown	Modulation of inclusion membrane stability.	[59, 100]
CT440	CTL0699	-	Unknown	Unknown.	[50]
CT442	CTL0701	CrpA	Unknown	Unknown.	[49, 50, 53, 59]
CT449	CTL0709	-	Unknown	Unknown.	[59]
CT483	CTL0744	-	Unknown	Unknown.	[52]
CT565	CTL0828	-	Unknown	Unknown.	[52]
CT618	CTL0882	-	Unknown	Associates with LDs.	[50, 54, 221]
CT813	CTL0184	InaC	14-3-3 proteins, ARF1/4, VAMP7/8	Modulation of post-translational modification of microtubules, and of F-actin and Golgi redistribution around the inclusion.	[15, 50, 52, 55, 74, 112]
CT850	CTL0223	-	DYNLT1	Inclusion positioning at the centrosomal region; localizes at inclusion microdomains.	[52, 128]

^aProteins with the characteristic hydrophobic bilobal domain and which have been experimentally detected at the inclusion membrane. See list of abbreviations and main text for abbreviations and protein nomenclature, respectively.

^bOnly interactions of C. trachomatis Incs (and not of Incs from other Chlamydia species) with host cell proteins were considered; while potential interactions between several C. trachomatis Incs and many human proteins have been described by large scale proteomics [85], only those further validated are specified in Table 1.