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. 2019 Jul 30;38(17):e101064. doi: 10.15252/embj.2018101064

Figure 4. Microglia dynamics depend on distance to Aβ deposition in APP/PS1 mice.

Figure 4

  1. Two‐photon images of microglia (eGFP) cells clustering around amyloid plaque for APP and APP/Nlrp3 −/− (5 and 15 months old). Scale bar: 20 μm.
  2. Quantification of morphological parameters in (A) (mean of 5–6 ± SEM).
  3. Flow cytometry plots from APP and APP/Nlrp3 −/− mice (15 months old), cells were gated on CD11b and MXO4 after microglia isolation.
  4. Relative Aβ microglia uptake quantification (mean of 5 ± SEM; two‐way ANOVA followed by Tukey's post hoc test, *P < 0.05).