Figure 7. Microglia proliferate in non‐APP mice upon peripheral immune challenge.

• A, B
  Iba‐1, Ki67, and DAPI staining in the cortex and hippocampus of wild‐type and Nlrp3 ^−/− (5 and 15 months old). Microglia proliferate upon LPS injection (white arrows). Non‐microglia cells proliferation was observed as well (yellow arrows). Scale bar: 20 μm.
• C
  Quantification of microglial proliferation in cortex (left panel) and hippocampus (right panel) (mean of 5 ± SEM; two‐way ANOVA followed by Tukey's post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001).