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. 2019 Aug 28;25(32):4682–4695. doi: 10.3748/wjg.v25.i32.4682

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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¹¹C-choline positron-emission tomography-computed tomography detected a tumor that was missed on conventional 2-deoxy-2-(¹⁸F)fluoro-D-glucose positron-emission tomography-computed tomography in a 58-year-old patient with hepatocellular carcinoma. A-D: 2-deoxy-2-(¹⁸F)fluoro-D-glucose positron-emission tomography-computed tomography (¹⁸F-FDG PET-CT) showed that there was no increased ¹⁸F-FDG uptake in the liver; E-H: ¹¹C-choline (¹¹C-CHOL) PET-CT showed focal increased ¹¹C-CHOL uptake in the upper segment of the anterior lobe of the liver, and the size of the lesion was 1.2 × 1.3 cm (blue arrow in F and G). Pathological examination confirmed well-differentiated hepatocellular carcinoma. ¹⁸F-FDG: 2-deoxy-2-(¹⁸F)fluoro-D-glucose; CT: Computed tomography; PET: Positron-emission tomography; ¹¹C-CHOL: ¹¹C-choline.