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CEST effect fitting of Lorentzian difference spectrum (MTRLD). The Lorentzian difference signal (Equation (5)) reveals CEST contrasts at individual offsets (A–C) and in the MTRLD spectrum in gray and white matter segments in a single slice (D). Error bars represent standard deviation across gray and white matter voxels, respectively, in a single subject. MTRLD is expressed in arbitrary units
