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. 2019 Aug 26;10:929. doi: 10.3389/fphar.2019.00929

Figure 4.

Figure 4

Zacopride improved Iso-induced maladaptive protein alterations in rat hearts. (A) Representative western blotting images 3 days, 10 days, and 30 days after the onset of Iso infusion. (B) Dynamic changes of Kir2.1 protein expression levels. (C) Dynamic changes of p-CaMKII protein expression levels relative to total CaMKII. (D) Dynamic changes in p-RyR2 protein expression levels relative to total RyR2. (E) Dynamic changes in SERCA2 protein expression. (F) Dynamic changes of cleaved caspase 3 protein expression. All data were normalized to control. Iso, isoproterenol; Zac, zacopride; Chlo, chloroquine. Data were presented as mean ± SEM (n = 3). *P < 0.05, **P < 0.01 compared with control. #P < 0.05, ##P < 0.01 compared with Iso+Zac.