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Zacopride restored RP depolarization and APD prolongation in isolated rat ventricular myocytes 10 days post-Iso infusion. These effects could be partially reversed by chloroquine. (A) Representative AP recording. (B) APD50 and APD90 in different groups. Iso, isoproterenol; Zac, zacopride; Chlo, chloroquine. N = 6 cells. Data were presented as mean ± SEM. *P < 0.05, **P < 0.01 compared with control. ##P < 0.01 compared with Iso+Zac.
