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Apoptosis of NRVMs following exposure to 1 μmol/L Iso for 24 h. (A) Cells in the lower right (LR) quarter represents early apoptosis. (B) Zacopride protected cardiomyocytes from Iso-induced apoptosis. IK1 channel blocker BaCl2 or chloroquine reversed the effects of Zac. Iso, isoproterenol; Zac, zacopride; Chlo, chloroquine. N = 5 parallel samples in each group. Data were presented as means ± SEM. **P < 0.01, compared with control. #P < 0.05, ##P < 0.01, compared with Iso+Zac.
