Table III.
Univariate and multivariate Cox proportional hazard models for overall survival of the GC patients (n=90).
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Clinicopathological features | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Sex | ||||
| Male | 1 (Reference) | |||
| Female | 0.80 (0.42–1.51) | 0.487 | ||
| Age (years) | ||||
| <70 | 1 (Reference) | 1 (Reference) | ||
| ≥70 | 1.82 (1.08–3.05) | 0.024 | 1.23 (0.69–2.18) | 0.487 |
| Histological grade | ||||
| G2 | 1 (Reference) | |||
| G3 | 1.45 (0.83–2.55) | 0.194 | ||
| Tumor size (cm) | ||||
| <5 | 1 (Reference) | 1 (Reference) | ||
| ≥5 | 3.68 (1.97–6.87) | <0.001 | 2.29 (1.15–4.55) | 0.018 |
| pT stage | ||||
| T1/T2 | 1 (Reference) | 1 (Reference) | ||
| T3/T4 | 1.74 (0.98–3.10) | 0.060 | 1.52 (0.79–2.94) | 0.208 |
| pN stage | ||||
| N0 | 1 (Reference) | 1 (Reference) | ||
| N1-N3 | 2.78 (1.40–5.50) | 0.003 | 2.20 (1.01–4.80) | 0.048 |
| pStage | ||||
| I/II | 1 (Reference) | |||
| III/IV | 3.38 (1.94–5.88) | <0.001 | ||
| Vessel invasion | ||||
| No | 1 (Reference) | |||
| Yes | 1.55 (0.82–2.92) | 0.176 | ||
| Nerve invasion | ||||
| No | 1 (Reference) | |||
| Yes | 1.56 (0.81–3.00) | 0.185 | ||
| CPXM2 expression | ||||
| Low | 1 (Reference) | 1 (Reference) | ||
| High | 2.07 (1.23–3.48) | 0.006 | 1.92 (1.08–3.40) | 0.026 |
P-values in bold print indicate a statistically significant result. CI, confidence interval; HR, hazard ratio; CPXM2, carboxypeptidase X, M14 family member 2.