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. Author manuscript; available in PMC: 2019 Sep 2.
Published in final edited form as: Bioorg Med Chem. 2018 Jun 12;26(14):3899–3908. doi: 10.1016/j.bmc.2018.06.010

Table 1.

Structures, yields and chemical properties of fused benzoimidazole-isoquinolines 7a–n.

graphic file with name nihms-1025847-t0005.jpg
Entry R1 R2 Comp. Yield (%)a CLogP tPSA
1 Cyclopropyl 2-thienyl 7a 82 3.799 52.65
2 iBu 2-thienyl 7b 52 4.8955 52.65
3 iBu 2-furanyl 7c 72 4.0715 61.88
4 2-BrC6H4 2-furanyl 7d 63 7.5791 52.65
5 2-BrC6H4 Acetyl 7e 75 4.672 52.65
6 2-BrC6H4 3-pyridyl 7f 71 5.5395 65.01
7 iBu 3-pyridyl 7g 72 3.7945 65.01
8 iBu 2-COOHC6H4 7h 76 4.9034 89.95
9 Bzl Ph 7i 62 6.0965 52.65
10 Ph Ph 7j 71 6.2375 52.65
11 Phenethyl 4-pyridyl 7k 67 4.4345 65.01
12 H Ph 7l 66 3.8747 61.44
13 2-BrC6H4 2-furanyl 7m 76 5.8165 61.88
14 2-BrC6H4 methyl 7n 78 3.5115 52.65
a

Isolated yield (%) from the one-pot procedure.