Study ID	Methods	Participants	Intervention	Outcomes	Notes
Campbell 1977Multiple pub: No	Study design: RCTRandomization procedure: adequateAllocation concealment: adequateFollow‐up: 26w	Country: ScotlandSetting: Community clinicNumber: 66Age: NRSex: NRMedications: 12% insulin; 44% oral treatmentBL wt: NRBL BMI: NRBL GHb: NR	Drug: PhentermineDosage: 30mg qdDuration: 26wDiet: NoneComparison: Placebo	Weight: YesBMI:>5% loss (%):FBS:GHb:Cholesterol:LDL:HDL:TG:SBP:DBP:Side effects: Yes; dry mouth and initial sleep disturbance	Funding: Riker Laboratories supplied the drugAbstract/full text: FTLOCF: NRITT: Yes, with attritionAttrition: 7%Blinding: Double‐blindBlinding assessor: UnclearBL comparable: NRJadad score:2,1,1,ARisk of bias: B
Gershberg 1972Multiple pub: Unclear if Gershberg 1977 is overlapping population	Study design: Unclear; 2 parallel groupsRandomization procedure: NRAllocation concealment: NRFollow‐up: 16w	Country: USASetting: NRNumber: 12Age: NRSex: NRMedications: NRBL wt: ave 143% ideal body weightBL BMI: NRBL GHb: NR	Drug: PhentermineDosage: NRDuration: 16wDiet: 1000kal/dComparison: Placebo + diet	Weight: YesBMI:>5% loss (%):FBS: YesCholesterol: YesLDL:HDL:TG: YesSBP:DBP:Side effects:	Funding: NRAbstract/full text: ALOCF: NRITT: NRAttrition: NRBlinding: Double‐blindBlinding assessor: UnclearBL comparable: NRJadad score:0,1,0,BRisk of bias: C
Gershberg 1977Multiple pub: Unclear if Gershberg 1972 is overlapping population	Study design: RCTRandomization procedure: UnclearAllocation concealment: NRFollow‐up: 16w	Country: USASetting: UnclearNumber: 22Age: NRSex: 64%FMedications: No insulinBL wt: I 85.0, C 84.1BL BMI: NRBL GHb: NR	Drug: PhentermineDosage: 30mg qdDuration: 16wDiet: 1000kcal/dComparison: Placebo + diet	Weight: YesBMI:>5% loss (%):FBS: YesGHb: Cholesterol: YesLDL:HDL:TG: YesSBP: YesDBP: YesSide effects: Yes; 3 pts complained of irritability and insomnia in the first week of RX; then subsided	Funding: NRAbstract/full text: FTLOCF: YesITT: CompleteAttrition: 9%Blinding: Double‐blindBlinding assessor: UnclearBL comparable: YesJadad score:1,1,1,BRisk of bias: B