Rissanen 1999a.

Methods	Study design: RCTRandomization procedure: NRAllocation concealment: Unclear Follow‐up: 52w
Participants	Country: FinlandSetting: NRNumber: 236Age: 18‐60ySex: NRMedications: Diet onlyBL wt: NRBL BMI: >28BL GHb: NR
Interventions	Drug: SibutramineDosage: 15mg qdDuration: 52wDiet: 700 kcal/d deficit dietComparison: Placebo + 700 kcal/d deficit diet
Outcomes	Weight: YesBMI:>5% loss (%): YesFBS:GHb: Yes Cholesterol: LDL:HDL: YesTG: YesSBP:DBP:Side effects:
Notes	Funding: NR Abstract/full text: A LOCF: NR ITT: NR Attrition: 11% Blinding: Double‐blind Blinding assessor: NR BL comparable: NR Jadad score: 1,1,0,B Risk of bias: C
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear