6. Assessment of consistency of the treatment effect with respect to lymph nodal status.

	Lymph nodal status
	Negative HR (95% CI)	Positive HR (95% CI)	RHR (95% CI)
BCIRG006	0.32 (0.17 to 0.62)	0.68 (0.52 to 0.86)	0.47 (0.23 to 0.94)
B31+N9831	0.47 (0.04 to 5.22)	0.48 (0.39 to 0.59)*	0.98 (0.09 to 11.23)
HERA	0.59 (0.39 to 0.91)	0.63 (0.51 to 0.78)*	0.94 (0.58 to 1.52)
NOAH	0.35 (0.09 to 1.29)	0.62 (0.39 to 0.98)	0.57 (0.14 to 2.32)
Summary			0.74 (0.51 to 1.08)

Q = 2.74 (dof = 3); P = 0.434; I² = 0

* The hazard ratios (HRs) were obtained by pooling the HRs reported by the authors at different cut‐points
CI: confidence interval
RHR: ratios of HR