Study	Reason for exclusion
Arroyo 2005	This is a non‐placebo controlled study
Bauer 1995	This is an open add‐on study of tiagabine in treatment of people with resistant partial and/or secondarily generalised seizures. In this study, the results reported were part of an ongoing multi‐national, multi‐centre trial. It is not randomised
Gustavson 1997	This is an open‐label, single‐dose study that was designed to examine the pharmacokinetics of tiagabine in children with epilepsy. It is not randomised
Uldall 1995	This is a single‐blind study of safety, tolerability and preliminary efficacy of tiagabine as adjunctive treatment of children with epilepsy. It is not randomised