2. Immunosuppressive treatment.
| Medicinal product | IST1 | Bayever 1984 | Führer 2005 |
| Dose and duration of therapy | |||
| Antithymocyte globulin | 40 mg/kg/day horse ATG for 4 days (1, 2, 3, 4) or 3.5 mg/kg/day; rabbit ATG for 5 days (1, 2, 3, 4, 5) Scheinberg 2011 |
20 mg/kg/day for 8 days (1, 2, 3, 4, 5, 6, 7, 8) | Führer 1998 reported antilymphocyte globulin 0.75 ml/kg/day for 8 days Führer 2005 reported horse ATG 0.75 ml/kg/day for 8 days |
| Methylprednisolone | 1 mg/kg/day for 14 days (1 to 14) and tapering off until day 28 | 40 mg/m2/day prednisone for 5 days (8, 9, 10, 11, 12) | Yes, as recommended |
| Ciclosporin | 5 mg/kg/day; starting on day 1 continued at least until day 112, further treatment depending upon response | NR | Yes, dose as recommended for at least 6 months |
1Recommended dose and duration of therapy according to Schrezenmeier 2000 unless indicated.
Abbreviation: ATG: antithymocyte globulin; IST: immunosuppressive therapy including ciclosporin and/or antithymocyte or antilymphocyte globulin; NR: not reported