Table 2.
Adverse events for interventions with drugs or food supplements
| Study | Intervention | Patients | Major adverse events | Minor adverse events |
| Bradley 1988 | Purified bovine brain gangliosides (Cronassial), five months 40 mg Cronassial versus five months 100mg Cronassial versus placebo | 30 CMT (clinical) | Allergic rash seen with 100mg in 2 patients, pain at injection site in one patient | 16.9% increased pain with medication versus 7.4% in the placebo group, 2.7% redness/itching versus 0.9% in placebo group, 6.8% skin rash versus 2.7% in the placebo group, tinnitus at the dose of 100mg in 2.7% versus 0.3% in the placebo group. |
| Smith 2006, Chetlin 2004 | Creatine monohydrate 5g/d combined with exercise | 39 CMT patients | None reported. | Mild gastrointestinal upset, leg cramps, fatigue, delayed‐onset soreness. |
| Sahenk 2005 | Neurotrophin‐3 starting with 50 µg/kg increasing up to 150 µg/kg | 4 CMT1A (genetically proven) | None reported. | Irritation at injection site, mild diarrhoea. |
| Prensky 1984 | Methylprednisolone 40 to 60 mg/m2 | 14 CMT clinical | Weight gain of 15 to 18 pounds in 3 patients, proximal myopathy and psychiatric illness in 1 patient (drop out), compression fracture of dorsal vertebrae T‐12 due to significant worsening of osteoporosis in 1 patient, severe leg cramps in 1 patient, pseudotumour when steroid was stopped in 1 patient, depression in 1 patient, hypertrophic nerve root in one patient. | None reported. |
| Russell 1995 | 3,4‐diaminopyridine (3,4‐DAP) 4x5mg/day up to 4x20mg/day | 27 CMT patients (clinical) | None reported. | 71% facial pain and predominantly perioral parasthesia with a maximum duration of 90 minutes, 29% muscle fatigue, 18% nauseas and abdominal discomfort, 15% insomnia, 12% transient urinary frequency, 6% increased tearing or nasal dicharge, 6% facial flushing, 6% transient hand tremor or muscle twitching, 6% headache, 6% transient parageusia. |
| Dyck 1982a, Dyck 1982b | Prednisone | Single cases | None reported. | None reported. |
| Folkers 1985, Folkers 1995 | Q10 | Single cases | None reported. | None reported. |
| Lisett 1998 | Growth hormone replacement | Single case | None reported. | None reported. |
| Jaradeh 1992 | Levodopa | 6 unspecified CMT cases. | None reported. | None reported. |
| Williams 1986 | Vitamin E combined with Cis‐linolein, gamma‐linoleic, oleic acid | 20 CMT patients (clinical). | None reported. | None reported. |