Skip to main content
. 2012 May 16;2012(5):CD007338. doi: 10.1002/14651858.CD007338.pub3

Standl 1998.

Methods Randomised clinical trial.
Participants Country: Germany. 
 Number randomised: 12. 
 Post‐randomisation drop‐outs: not stated. 
 Mean age: 59 years. 
 Females: 6 (50.0%). 
 Major liver resections: 5 (41.7%). 
 Cirrhotic livers: 0 (0%).
Inclusion criteria: 
 Elective liver resection.
Exclusion criteria

  1. Severe cardiovascular disease (uncontrolled hypertension > 180/100 mm Hg, recent myocardial infarction <6 months, unstable angina, congestive heart failure)

  2. Decompensated pulmonary disease

  3. Porphyria

  4. Acute or chronical hepatic infections (eg, hepatitis B and C)

  5. Liver cirrhosis

  6. Anaemia (pre‐operative packed cell volume < 30% or haemoglobin <10 g/ dl)

  7. Allergic reactions to beef products.
Interventions Participants were randomly assigned to two groups.
Group 1: HBOC‐201 (n = 6). 
 Group 2: control (n = 6).
Further details of intervention and control: 
 Pre‐operative haemodilution was performed after induction of anaesthesia (1 litre autologous blood donation followed by 2 litres of RL) followed by intervention or control within 30 minutes.
Other details: 
 Vascular occlusion: not stated. 
 Method of parenchymal transection: not stated. 
 Management of raw surface: not stated. 
 Other co‐interventions to decrease blood loss: none reported.
Outcomes The outcome measures were mortality, transfusion requirements, peri‐operative morbidity, operating time, hospital stay, blood loss, and liver function tests.
Notes Attempts to contact the authors in November 2008 were unsuccessful.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: This information was not available.
Allocation concealment (selection bias) Unclear risk Comment: This information was not available.
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Comment: This information was not available.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: This information was not available.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Comment: This information was not available.
Selective reporting (reporting bias) High risk Comment: Important outcomes such as liver failure were not reported.
Free of vested interest bias? Unclear risk Comment: This information was not available.