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. 2012 May 16;2012(5):CD007338. doi: 10.1002/14651858.CD007338.pub3

Yao 2006.

Methods Randomised clinical trial.
Participants Country: China. 
 Number randomised: 30. 
 Post‐randomisation drop‐outs: not stated. 
 Mean age: not stated. 
 Females: 14 (46.7%). 
 Major liver resections: not stated. 
 Cirrhotic livers: not stated.
Inclusion criteria:

  1. Hepatic resection

  2. Hb above 12 mg/dl

  3. Hct above 35%

  4. Albumin over 35 g/l

  5. ASA I‐II.
Interventions Participants were randomly assigned to three groups.
Group 1: acute normovolemic haemodilution with hypotension (n = 10). 
 Group 2: acute normovolemic haemodilution without hypotension (n = 10). 
 Group 3: control (n = 10).
Further details of intervention:
Group 1: dilution with crystalloid solution (10ml/kg), autologous blood donation (replaced with 6% HES), and reduced the MAP to 70% with 0.01% sodium nitroprusside (1 mcg/kg/min). 
 Group 2: dilution with crystalloid solution (10ml/kg) and autologous blood donation (replaced with 6% HES). 
 Group 3: control.
Other details: 
 Vascular occlusion: not stated. 
 Method of parenchymal transection: not stated. 
 Management of raw surface: not stated. 
 Other co‐interventions to decrease blood loss: none reported.
Outcomes The outcomes reported were mortality, transfusion requirements, and operative blood loss.
Notes Attempts to contact the authors in December 2008 were unsuccessful.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: This information was not available.
Allocation concealment (selection bias) Unclear risk Comment: This information was not available.
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Comment: This information was not available.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: This information was not available.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Comment: This information was not available.
Selective reporting (reporting bias) High risk Comment: Important outcomes such as liver failure were not reported.
Free of vested interest bias? Unclear risk Comment: This information was not available.

CUSA = cavitron ultrasonic surgical aspirator 
 CVP = central venous pressure 
 MAP = mean arterial pressure 
 PTC = portal triad clamping