Comparison 2. Oral (single dose) vitamin K vs. placebo or nothing.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 PIVKA II present	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 At 3 days	3	118	Risk Ratio (M‐H, Fixed, 95% CI)	0.40 [0.26, 0.61]
1.2 At 5 days	1	86	Risk Ratio (M‐H, Fixed, 95% CI)	0.22 [0.08, 0.56]
1.3 At 1 month	1	17	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Prothrombin time (seconds)	1	26	Mean Difference (IV, Fixed, 95% CI)	‐2.5 [‐4.26, ‐0.74]
2.1 At 3 days	1	26	Mean Difference (IV, Fixed, 95% CI)	‐2.5 [‐4.26, ‐0.74]
3 Echis factor II	1	26	Mean Difference (IV, Fixed, 95% CI)	0.11 [‐0.01, 0.23]
3.1 At 3 days	1	26	Mean Difference (IV, Fixed, 95% CI)	0.11 [‐0.01, 0.23]
4 Ratio factor II/ Echis II	1	26	Mean Difference (IV, Fixed, 95% CI)	0.37 [0.06, 0.68]
4.1 At 3 days	1	26	Mean Difference (IV, Fixed, 95% CI)	0.37 [0.06, 0.68]
5 Prothrombin index (% of normal)	1	50	Mean Difference (IV, Fixed, 95% CI)	12.10 [4.70, 19.50]
5.1 At 1‐7 days	1	50	Mean Difference (IV, Fixed, 95% CI)	12.10 [4.70, 19.50]