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. 2019 Sep 2;10:3922. doi: 10.1038/s41467-019-11929-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Validation of ART-associated differentially methylated regions in an unrelated cohort. a. Summary of three ART-DMRs that are detected in both neonatal and adult blood. b Scatterplot of individual probes within the three DMRs at CHRNE, PRSS16 and TMEM18 genes, with mean Δβ for neonatal blood in our cohort (CHART) shown on y axis and mean Δβ for neonatal blood in the 450K cohort shown on x axis. DMRs at CHRNE and PRSS16 correlate well between the two studies. c Map of the CHRNE gene in hg19, showing EPIC probe locations and mean DNA methylation level at the ART-DMR in the 450K study. d Map of the PRSS16 gene in hg19, showing EPIC probe locations and mean DNA methylation level at the ART-DMR in the 4 study. Error bars are 95% CI. n = 133 biologically independent birth samples