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. 2019 Sep 2;10:3922. doi: 10.1038/s41467-019-11929-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — No evidence for ART-associated DNA methylation change at imprinted genes. a Strategy for analysis of DNA methylation at imprinted gene regions. A total of 706 probes mapped within 50 imprinted regions. b Column plot showing the percentage of all probes and probes at imprinted regions showing a difference between ART and non-ART groups at an unadjusted p-value <0.05 (Bayesian levene’s test). This analysis shows that imprinted regions are less likely to have an ART-associated DNA methylation change than the average gene region. c Correlation plot of mean DNA methylation change between ART and non-ART in neonatal (x-axis) and adult (y-axis) blood at all imprinted probes. This shows that no probes show a Δβ ≥ 4% in adults, while only two probes meets this criteria in neonatal blood. d Bar plot of neonatal (red) and adult (blue) blood Δβ values for top ranked imprinted probes based on methylation change in neonatal or adult blood, with name of nearest gene