Table 1.
Discovery, replication, and combined results for the lead SNP rs7594852 at the 2q13 locus
| rs7594852 effect allele (C) frequency | Number | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Phenotype | Sample sets | Cases | Controls | Cases | Controls | Beta/ORa (95% CI) | P | I2 (95% CI) | P het |
| Gestational duration | Combined discovery | 0.53 | 84,689 | 0.034 (0.024−0.043) | 1.88 × 10−12 | 0 (0.0−13.4) | 0.97 | ||
| MoBa_HARVEST | 0.54 | 7072 | 0.049 (0.016−0.082) | 3.78 × 10−3 | |||||
| BiB | 0.51 | 1354 | 0.058 (−0.028−0.144) | 0.18 | |||||
| FIN | 0.58 | 865 | 0.004 (−0.056−0.065) | 0.89 | |||||
| Combined replication | 9291 | 0.041 (0.013−0.068) | 3.69 × 10−3 | 0 (0.0−97.4) | 0.41 | ||||
| All combined | 93,980 | 0.034 (0.025−0.043) | 3.96 × 10−14 | 0 (0.0−99.6) | 0.64 | ||||
| Postterm birth | Combined discovery | 0.55 | 0.53 | 7888 | 52,807 | 1.1 (1.06−1.14) | 4.64 × 10−8 | 7.3 (0.0−88.1) | 0.37 |
| MoBa_HARVEST | 0.55 | 0.54 | 670 | 5626 | 1.05 (0.89−1.24) | 0.39 | |||
| All combined | 8558 | 58,433 | 1.1 (1.06−1.14) | 4.34 × 10−8 | 0 (0.0−99.7) | 0.58 | |||
aFor the quantitative trait of quantile transformed gestational duration, the column reports beta estimates. For the dichotomous trait postterm birth, odds ratio (OR) estimates are given; CI, confidence interval; I2, heterogeneity estimate (proportion of variance that is due to between study differences); Phet, P value from the Cochran Q test of between study heterogeneity. Individual study association P values are two-sided and obtained by linear regression (for quantile transformed gestational duration) or logistic regression (for postterm birth). Combined P values are also two-sided and obtained from fixed-effects inverse-variance-weighted meta-analysis