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Adipose hFXR causes collagen deposition and alters adipose architecture. Collagen characterization in iWAT (A) and eWAT (B) of chow-fed FXR−/− and FXR−/− aP2-hFXR mice by picrosirius red staining. Collagen I and lamin-A/C protein levels (C) and quantification in eWAT of chow-fed FXR−/− and FXR−/− aP2-hFXR mice (D) (n = 6; data are represented as mean ± SEM; *P < 0.05, **P < 0.01). Scale bar represents 200 μm.
