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. 2019 Aug 27;10:1955. doi: 10.3389/fimmu.2019.01955

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Copyright © 2019 Ricci, Lodi, Serranti, Moroni, Belli, Mancano, La Barbera, Forzano, Mangone, Indolfi and Azzari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representation of 73 patients reported in literature (1, 6, 8–22). 60% of patients (gray area) did not undergo complete immune characterization. 44% of patients who underwent immune characterization presented an immunological impairment (red area).