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. 2019 Aug 27;10:1958. doi: 10.3389/fimmu.2019.01958

Table 1.

Classical FcγRs and their expression on neutrophils.

Structure graphic file with name fimmu-10-01958-i0001.jpg
Name FcγRI FcγRIIA FcγRIIB FcγRIIC FcγRIIIA FcγRIIIB
CD CD64 CD32A CD32B CD32C CD16A CD16B
Gene FCGR1A FCGR2A FCGR2B FCGR2C FCGR3A FCGR3B
Alleles – H131 R131 I232 T232 Q57 stop57 V176 F176 NA1 NA2 SH
Affinity High Low to medium Low to medium Low to medium Low to medium Low to medium
Expression on resting neutrophils < 2,000 copies 30,000–60,000 copies Low to none; increase when 2B4 promotor haplotype Low to none Low to none 100,000–200,000 copies
Neutrophil expression in inflammatory conditions Up to 10-fold increased expression in presence of IFN-γ and G-CSF Upregulated in presence TNF-α Low to none; increase when 2B4 promotor haplotype Low to none Low to none 100,000–200,000 copies, subject to shedding