Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 27;10:1902. doi: 10.3389/fimmu.2019.01902

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Waller, James, de Jong, Blackmore, Ma, Stagg, Kelsell, O'Dwyer, Hutchins and Alazawi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

CD16⁺ monocytes are reduced in acute pancreatitits and in response to LPS. Representative flow cytometry plots showing monocyte subsets in (A) healthy controls or (B) patients with acute pancreatitis (AP). Monocytes were identified by forward and side scatter, HLA-DR positivity and classified according to the expression of CD14 and CD16. (C) Proportion of intermediate monocytes was significantly reduced in patients with AP compared with controls (p = 0.008). (D) Proportion of non-classical monocytes was reduced in patients with AP compared to controls [3.4 vs. 6.3% (E)]. Patients with AP had reduced levels of NFκBp65 phosphorylation at S529 in monocytes stimulated with LPS compared with controls (p = 0.001, percentage increase over unstimulated baseline). (F) Patients with AP had reduced LPS-induced IL-6 production from PBMCs compared to controls (p = 0.006).